Lupus miliaris disseminatus faciei (LMDF) is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly. A biopsy specimen revealed epithelioid cell granulomas with central necrosis, consistent with a diagnosis of lupus miliaris disseminatus faciei (Figure 2). Lupus miliaris disseminatus faciei (LMDF) first described in is an uncommon dermatosis of unknown etiology with characteristic.

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This entity has been described with a variety of names including acne agminata, acnitis, papular tuberculid, lupoid rosacea, and the more recent facial idiopathic granulomas with regressive evolution F. A tendency toward periappendageal localization of the granulomas was also noted.

Significant clinical improvements in skin lesions were noted 4 weeks after the first treatment. A variety of treatments including tetracyclines, dapsone, isotretinoin, tranilast, oral corticosteroids, and combination therapies have shown variable efficacy in LMDF [ 151011 ].


May 19, ; Accepted date: None, Conflict disseminatux Interest: Further information is needed to clarify the diagnosis, etiology, and pathogenesis of this disease, but an unusual host response to folliculitis or follicular injury likely plays a role in most cases.

Our patient could not tolerate tetracycline-class antibiotics, and her disease was resistant to treatment with several systemic agents, including erythromycin, isotretinoin, and prednisone. Small pustules may rarely accompany the papules [ 3disssminatus ]. Now a days, it is considered to be a variant of rosacea. Lupus Miliaris disseminatus faciei: A few lesions showed scaling on the surface.


It presents with pale papules which may be confused with sarcoid or syringoma clinically. Lupus miliaris disseminatus faciei, Part II: Select your language of interest to view the total content in your interested language. Additionally, sarcoidosis can be distinguished by physical examination, chest X-ray, and laboratory tests, and infectious disorders by the absence of microorganisms detected through histochemical stains PAS, Ziehl-Neelsen.

Muller J Med Sci Res ;8: Sign in to customize milirais interests Sign in to your personal account. A clinical and histologic study of granulomatous rosacea. A year-old male presented with 4 months history of asymptomatic, reddish-raised lesions over the face, earlobes, and the neck.

The following histologic features are also characteristic: Br J Dermatol ; The treatment of acne agminata with clofazimine. Caseation necrosis is variable and usually seen in fully developed LMDF lesions. In our report of 10 patients, the presence of an epithelioid granuloma with miliariis caseation necrosis or necrobiosis was the requirement for histologic diagnosis. Andrews’ Diseases of the Skin.

Limiting the histologic diagnosis to fully developed lesions demonstrating epithelioid granulomas with caseation necrosis serves to clarify the diagnosis in the setting of diverse clinical presentations. Diascopy may reveal apple-jelly nodules [ 1 – 3 ].

In our study of 10 patients, we have found clinical presentations that vary from the classic description of LMDF. Low A and high B magnification of a biopsy specimen from a cheek lesion. All cases demonstrated epithelioid granulomas with a central area of caseation necrosis. facie

Lupus miliaris disseminatus faciei

Though efficacy is difficult to determine in this spontaneously resolving dermatosis, early diagnosis and treatment has demonstrated prevention of scar formation [ 1 ]. Axillary acne dissseminatus lupus miliaris disseminatus faciei.


Sign in to access your subscriptions Sign in to your personal account. Open in a separate window. Mycobacterial and fungal infections may be ruled out with special stains Ziehl Neelson and GMS respectively.

The average size of the lesions was 3. Lupus miliaris disseminatus faciei. A trial of anti-tubercular therapy was given for 2 months, but no response was seen, rather he had developed some new lesions including one papule on the right upper chest. Purchase access Subscribe to JN Learning for one year.

Support Center Support Center. Lupus miliaris disseminatus faciei — The Fciei of Mycobacterium tuberculosis is not detectable in active lesions by polymerase chain reaction.

From January to Septemberthe records of 10 patients with a histopathologic diagnosis of lupus miliaris disseminatus faciei were collected from our dermatopathology archive.

Friedman, MD ; Sharon R. Sarcoidosis — Typically lacks caseating necrosis dissemintaus may show some fibrinoid degeneration within the granulomas which can cause confusion. Disruption of hair follicles in approximation to the granulomas was noted in two cases Figure 1B and Figure 2B. LMDF has been considered to miliarris a form of granulomatous rosacea, supported by the frequent close association with pilosebaceous units [ 117 ].

Fragmented skin biopsy showing mild focal acanthosis with focal follicular plugging.